Toxicology studies the adverse effects of chemical, physical, or
biological agents on people, animals, and the environment. It is a branch of
science that studies the nature and action of poisons and also the adverse
health effects of chemical materials. Toxicology is also a dynamic
multidisciplinary science, as it requires interactions between biology,
chemistry, medicine, veterinary medicine, pharmacy and environmental science.
Toxicology interconnects research, hazard and risk assessment and risk
management, to protect public health.
Many chemicals and drugs can have the ability to produce injury on
lives once it reaches a susceptible site, and scientists use toxicity to
describe the degree to which a substance can harm humans or animals. Toxicity
can be acute, subchronic, or chronic.
Acute toxicity refers to those adverse effects occurring following
oral or dermal administration of a single dose of a substance, or multiple
doses given within 24 hours, or an inhalation exposure of 4 hours. Acute
toxicity is distinguished from chronic toxicity in that chronic toxicity describes
the adverse health effects from repeated exposures, often at lower levels, to a
substance over a longer time period.
Testing for acute toxicity is very fundamental in toxicological study.
Acute toxicity study is routinely performed as a regulatory requirement for many
substance and product types for purpose to ensure human safety. The results of
these studies are used to characterize the hazard, to assign the substance to a
classification category, and also help provide information on the likely
medical treatment of an overexposure and to inform the design of subsequent
longer-term toxicity studies where these are required.
The relative simplicity of the study design and the endpoints
investigated makes acute toxicity studies obvious candidates for replacement by
alternative methods, and while there has been some progress in the development
of these alternatives, regulatory acceptance is currently limited. At present,
incorporation of the use of read-across and the available in vitro and in
silico methods, with in vivo studies performed only when required, is
recommended in order to give an intelligent and integrated strategy to the
assessment of acute toxicity.
In the area of general toxicology, Creative Animodel offers
customers standard protocols designed to support drug approval submissions to
domestic and international regulatory agencies. Creative Animodel performs
acute toxicity tests by staff experts who have rich experience in doing toxicological
study.
For acute toxicity or toxicology service, please contact us at info@Creative-Animodel.com for project
discussion.
