Acute Toxicity Study in Toxicology

Toxicology studies the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. It is a branch of science that studies the nature and action of poisons and also the adverse health effects of chemical materials. Toxicology is also a dynamic multidisciplinary science, as it requires interactions between biology, chemistry, medicine, veterinary medicine, pharmacy and environmental science. Toxicology interconnects research, hazard and risk assessment and risk management, to protect public health.

Many chemicals and drugs can have the ability to produce injury on lives once it reaches a susceptible site, and scientists use toxicity to describe the degree to which a substance can harm humans or animals. Toxicity can be acute, subchronic, or chronic.

Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours. Acute toxicity is distinguished from chronic toxicity in that chronic toxicity describes the adverse health effects from repeated exposures, often at lower levels, to a substance over a longer time period.

Testing for acute toxicity is very fundamental in toxicological study. Acute toxicity study is routinely performed as a regulatory requirement for many substance and product types for purpose to ensure human safety. The results of these studies are used to characterize the hazard, to assign the substance to a classification category, and also help provide information on the likely medical treatment of an overexposure and to inform the design of subsequent longer-term toxicity studies where these are required.

The relative simplicity of the study design and the endpoints investigated makes acute toxicity studies obvious candidates for replacement by alternative methods, and while there has been some progress in the development of these alternatives, regulatory acceptance is currently limited. At present, incorporation of the use of read-across and the available in vitro and in silico methods, with in vivo studies performed only when required, is recommended in order to give an intelligent and integrated strategy to the assessment of acute toxicity.

In the area of general toxicology, Creative Animodel offers customers standard protocols designed to support drug approval submissions to domestic and international regulatory agencies. Creative Animodel performs acute toxicity tests by staff experts who have rich experience in doing toxicological study.

For acute toxicity or toxicology service, please contact us at info@Creative-Animodel.com for project discussion.